• Zhongping Shi, Jun Wang, Shanjiang Chen, Haiyue Dai, and Yiwei Huang.
• Wenzhou Central Hospital, Wenzhou, Zhejiang Province, China.
• Medicine (Baltimore). 2021 Jan 29; 100 (4): e24407e24407.

BackgroundArteriosclerosis has genetic correlation. Many studies have shown that angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism is highly associated with arteriosclerosis, but there is no evidence-based basis. The purpose of this study is to systematically evaluate the relationship between AT1R gene A1166C polymorphism and arteriosclerosis.MethodsThe search time is set from the establishment of the database in December 2020 in this study. The search database include China National Knowledge Infrastructure (CNKI), Wanfang, VIP and China Biology Medicine disc (CBM), PubMed, EMBASE, Web of Science, and the Cochrane Library. The subjects are observational studies on the relationship between AGTR1 A1166C polymorphism and arteriosclerosis (including case-control study, cross-sectional study, and cohort study). The language is limited to English and Chinese. The data of the included study are extracted and the literature quality is evaluated by 2 researchers independently. The data are statistically analyzed by Stata 16.0 software.ResultsThis study will use pulse wave velocity as an index to evaluate arteriosclerosis to explore the relationship between AT1R gene A1166C polymorphism and arteriosclerosis.ConclusionThis study will provide evidence-based medicine for elucidating the genetic tendency of arteriosclerosis.Ethics And DisseminationPrivate information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval will not be required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.Osf Registration NumberDOI 10.17605/OSF.IO/V6E2Y.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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