• Süleyman Günay, Betül Paköz, Cem Çekiç, Hakan Çamyar, Emrah Alper, Elif Saritaş Yüksel, Firdevs Topal, and Ömer Burcak Binicier.
• Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, Izmir.
• Medicine (Baltimore). 2021 Jan 22; 100 (3): e23175.

AbstractHydrogen peroxide is a liquid that functions in mechanical removal of the necrotic tissue via the elimination of tissue debris.In this study, we aimed to evaluate the effectiveness of the use of hydrogen peroxide in necrosectomy treatment of walled-off pancreatic necrosis.Records of 24 patients who were diagnosed with pancreatic necrosis or walled-off pancreatic necrosis and underwent endoscopic necrosectomy (EN) were retrospectively assessed. Patients were divided into 2 groups; hydrogen peroxide used for treatment or not used, and these 2 groups were compared.A total of 24 patients underwent endoscopic intervention for walled-off pancreatic necrosis. Procedural success was comparable between the 2 groups. During the post-procedural follow-up, the duration of the hospital stay, recurrence, and complication rates were found to be similar in both groups. The mean number of the endoscopic interventions was significantly lower in the hydrogen peroxide group (4.2 ± 1.4 vs 6.1 ± 4.2; P = .01).The use of hydrogen peroxide for EN in walled-off pancreatic necrosis patients seems to have similar efficiency and safety. However, it can be said that the use of hydrogen peroxide could reduce the number of endoscopic procedures.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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