• Fengyuan Wu, Ying Zhang, Yunpeng Cheng, Yan Lu, Yinong Jiang, and Wei Song.
• Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
• Medicine (Baltimore). 2021 Jan 22; 100 (3): e24305.

RationaleMedullary sponge kidney (MSK) is a congenital renal disorder characterized by recurrent nephrolithiasis or nephrocalcinosis. Recently, it has been found that MSK can be also combined with other diseases, such as primary aldosteronism and Beckwith-Wiedemann, but whether it is associated with secondary hypertension remains unknown.Patient ConcernsA 22-year-old hypertensive female presented to our hospital characterized by hypokalemia and hypertension.DiagnosisThe laboratory examination showed secondary aldosteronism. And the common causes for secondary aldosteronism include renal artery stenosis, glomerulonephritis, lupus nephropathy, and diabetic nephropathy, all of which were excluded except MSK.InterventionsShe was treated with angiotensin-converting enzyme inhibitors.OutcomesHer blood pressure, serum potassium, and plasma renin levels were reversed after treatment with angiotensin-converting enzyme inhibitors.LessonsWe presumed that MSK may be associated with secondary hypertension, and the mechanism may be the activation of the renin-angiotensin-aldosterone system.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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