• Semin Respir Crit Care Med · Apr 2021

    Review

    Aggressive Therapy for Acute Pulmonary Embolism: Systemic Thrombolysis and Catheter-Directed Approaches.

    • Thomas M Todoran and Bradley Petkovich.
    • Division of Cardiovascular Medicine, Medical University of South Carolina, Charleston, South Carolina.
    • Semin Respir Crit Care Med. 2021 Apr 1; 42 (2): 250-262.

    AbstractVenous thromboembolism (VTE) is the third most common cause of cardiovascular disease after myocardial infarction and stroke. Population-based studies estimate that up to 94,000 new cases of pulmonary embolism (PE) occur in the United States annually with an increasing incidence with age. Mortality from PE is the greatest in the first 24 hours, with a decreased survival extending out 3 months. Thus, acute PE is a potentially fatal illness if not recognized and treated in a timely manner. Contemporary management includes systemic anticoagulation, thrombolysis, catheter-based procedures, and surgical embolectomy. This article reviews current clinical evidence and societal guidelines for the use of systemic and catheter-directed thrombolysis for treatment of acute PE.Thieme. All rights reserved.

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