• Neomi Shah, Matthew Allison, Yanping Teng, Sylvia Wassertheil-Smoller, Daniela Sotres-Alvarez, Alberto R Ramos, Phyllis C Zee, Michael H Criqui, Henry K Yaggi, Linda C Gallo, Susan Redline, and Robert C Kaplan.
• From the Department of Medicine, Montefiore Medical Center (N.S.) and Department of Epidemiology and Population Health (N.S., S.W.-S., R.C.K.), Albert Einstein College of Medicine, Bronx, NY; Department of Medicine, University of Southern California San Diego, La Jolla (M.A., M.H.C., L.C.G.); Department of Biostatistics, Collaborative Studies Coordinating Center, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (Y.T., D.S.-A.); Department of Medicine, University of Miami, FL (A.R.R.); Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL (P.C.Z.); Department of Medicine, Yale School of Medicine, New Haven, CT (H.K.Y.); and Department of Medicine, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (S.R.). nshah@montefiore.org.
• Arterioscler. Thromb. Vasc. Biol. 2015 Mar 1; 35 (3): 710-5.

ObjectiveSleep apnea (SA) has been linked with various forms of cardiovascular disease, but little is known about its association with peripheral artery disease (PAD) measured using the ankle-brachial index. This relationship was evaluated in the Hispanic Community Health Study/Study of Latinos.Approach And ResultsWe studied 8367 Hispanic Community Health Study/Study of Latinos participants who were 45 to 74 years of age. Sleep symptoms were examined with the self-reported Sleep Health Questionnaire. SA was assessed using an in-home sleep study. Systolic blood pressure was measured in all extremities to compute the ankle-brachial index. PAD was defined as ankle-brachial index <0.90 in either leg. Multivariable logistic regression was used to investigate the association between moderate-to-severe SA, defined as apnea-hypopnea index ≥15, and the presence of PAD. Analyses were adjusted for covariates. The prevalence of PAD was 4.7% (n=390). The mean apnea-hypopnea index was significantly higher among adults with PAD compared with those without (11.1 versus 8.6 events/h; P=0.046). After adjusting for covariates, moderate-to-severe SA was associated with a 70% increase in the odds of PAD (odds ratio, 1.7; 95% confidence interval, 1.1-2.5; P=0.0152). This association was not modified by sex (P=0.8739). However, there was evidence that the association between moderate-to-severe SA and PAD varied by Hispanic/Latino background (P<0.01). Specifically, the odds were stronger in Mexican (adjusted odds ratio, 2.9; 95% confidence interval, 1.3-6.2) and in Puerto Rican Americans (adjusted odds ratio, 2.0; 95% confidence interval, 0.97-4.2) than in other backgrounds.ConclusionsModerate-to-severe SA is associated with higher odds of PAD in Hispanic/Latino adults.© 2015 American Heart Association, Inc.

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