• Peng-Fei Liu, Da-Hui Zhao, Yan Qi, Jian-Guo Wang, Ming Zhao, Kun Xiao, and Li-Xin Xie.
• Department of Pulmonary & Critical Care Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
• Clin Respir J. 2018 Jan 1; 12 (1): 23-30.

Introduction And ObjectivesTo investigate the clinical value of fractional exhaled nitric oxide (FeNO) in lung cancer patients.MethodsA total of 172 healthy control subjects and 164 patients with histopathologically confirmed lung cancer were enrolled in this study. The FeNO measurements and pulmonary function tests were conducted in the Chinese PLA General Hospital. The recorded data included FeNO, the forced expiratory volume in one second (FEV1 ), the forced vital capacity (FVC), FEV1 /FVC, the FEV1 (% predicted), the demographic characteristics, the presence of complications and the smoking status.ResultsThe patients with lung cancer had a significantly higher level of eNO than the healthy control subjects (33.85 ± 15.63 ppb, n = 163; 16.83 ± 4.17 ppb, n = 172; P < 0.01). The areas under receiver operating characteristic curves for eNO predicting airway inflammation in lung cancer subjects and healthy control subjects was 0.932 (95% confidence interval: 0.904-0.961). In the lung cancer group, the eNO levels in the squamous cell carcinoma, adenocarcinoma, small-cell lung cancer and lung carcinoid tumor groups were significantly different (P < 0.01). Lung cancer patients with a predicted FEV1 % value <80% had a higher level of eNO than the patients with a predicted FEV1 % value ≥80%.ConclusionsThe eNO levels in patients with lung cancer were higher than the normal level, especially in the patients with squamous cell carcinoma and small-cell lung cancer. The differences in eNO among the lung cancer subtypes were statistically significant. Measuring eNO will be helpful in diagnosing airway inflammation in lung cancer and in the classification of lung cancer.© 2016 The Authors. The Clinical Respiratory Journal Published by John Wiley & Sons Ltd.

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