• J R Soc Med · Jan 1986

    Randomized Controlled Trial Comparative Study Clinical Trial

    Atropine or glycopyrrolate with neostigmine 5 mg: a comparative dose-response study.

    • M G Salem and R S Ahearn.
    • J R Soc Med. 1986 Jan 1; 79 (1): 19-21.

    AbstractOne hundred and fifteen patients, separated into 4 groups, received neostigmine 5 mg with either atropine 1.2 mg or 1.8 mg, or glycopyrrolate 0.6 mg or 0.9 mg. Those receiving 0.9 mg glycopyrrolate had insignificant changes in heart rate in the immediate postreversal period. It is recommended that when glycopyrrolate is used with 5 mg neostigmine, the optimum dose is 0.9 mg.

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