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- K A Josephs, D S Knopman, J L Whitwell, B F Boeve, J E Parisi, R C Petersen, and D W Dickson.
- Department of Neurology, Mayo Clinic, 200 First St S.W., Rochester, MN 55905, USA. josephs.keith@mayo.edu
- Neurology. 2005 Aug 23; 65 (4): 645-7.
AbstractPathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.
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