• Neurology · Jan 2006

    Comparative Study

    Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration.

    • Jennifer L Whitwell, Clifford R Jack, Matthew L Senjem, and Keith A Josephs.
    • Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
    • Neurology. 2006 Jan 10; 66 (1): 102-4.

    AbstractThe authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.

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