• T Mouillot, M-C Brindisi, C Chambrier, S Audia, and L Brondel.
• Service d'hépato-gastro-entérologie, CHU F.-Mitterrand, 21000 Dijon, France; AgroSup Dijon, CNRS, Inrae, centre des sciences du goût et de l'alimentation, université Bourgogne Franche-Comté, 21000 Dijon, France. Electronic address: thomas.mouillot@chu-dijon.fr.
• Rev Med Interne. 2021 May 1; 42 (5): 346-354.

AbstractRefeeding syndrome (RS) is a rare but severe condition that is poorly understood, often under-diagnosed and can lead to death. It occurs within 5 days after refeeding in patients after prolonged fasting or in a context of undernutrition. As a consequence of the abrupt transition from catabolism to anabolism, RS is defined as a decrease in plasma levels of phosphorus, potassium and/or magnesium, whether or not associated with organ dysfunction resulting from a decrease in one of the electrolytes or a thiamine deficiency, after refeeding. The clinical symptoms are varied and non-specific and are related to hydro electrolyte disorders, sodium-hydroxide retention or failure of one or more organs. Patient management should be appropriate with regular clinical examination and careful biological monitoring, including hydro electrolyte monitoring. The correction of hydroelectrolytic disorders and systematic thiamine supplementation are essential during refeeding, that must be done carefully and very progressively, whatever its form (oral, enteral or parenteral). The severity of the refeeding syndrome indicates that its prevention and screening are the corners of its management in at-risk patients.Copyright © 2020. Published by Elsevier Masson SAS.

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