• J. Alzheimers Dis. · Jan 2015

    Comparative Study

    Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease.

    • Marcella Catania, Giuseppe Di Fede, Elisa Tonoli, Luisa Benussi, Claudio Pasquali, Giorgio Giaccone, Emanuela Maderna, Roberta Ghidoni, and Fabrizio Tagliavini.
    • Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
    • J. Alzheimers Dis. 2015 Jan 1; 47 (4): 877-81.

    AbstractAlzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation in brain that is paralleled by Aβ(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of Aβ peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct Aβ profile in CSF and brain deposits and (ii) the CSF Aβ pattern mirrors the Aβ profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

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