• Fanny Nusbaum, Jérome Redouté, Didier Le Bars, Pierre Volckmann, François Simon, Salem Hannoun, Gérard Ribes, Jacques Gaucher, Bernard Laurent, and Dominique Sappey-Marinier.
• University of Lyon II, Laboratoire Santé-Individu-Société, 5 avenue Pierre Mendès France – Bâtiment K – 69500 Bron, France. f.nusbaum@wanadoo.fr
• Int J Clin Exp Hypn. 2011 Jan 1; 59 (1): 27-44.

AbstractThis study aimed to characterize the neural networks involved in patients with chronic low-back pain during hypnoanalgesia. PET was performed in 2 states of consciousness, normal alertness and hypnosis. Two groups of patients received direct or indirect analgesic suggestion. The normal alertness state showed activations in a cognitive-sensory pain modulation network, including frontotemporal cortex, insula, somatosensory cortex, and cerebellum. The hypnotic state activated an emotional pain modulation network, including frontotemporal cortex, insula, caudate, accumbens, lenticular nuclei, and anterior cingulate cortex (ACC). Direct suggestion activated cognitive processes via frontal, prefrontal, and orbitofrontal cortices, while indirect suggestion activated a widespread and more emotional network including frontal cortex, anterior insula, inferior parietal lobule, lenticular nucleus, and ACC. Confirmed by visual analog scale data, these results suggest that chronic pain modulation is greater with hypnosis, which enhances both activated networks.

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