• J Pain Symptom Manage · Sep 2021

    Examining Adherence and Dose Effect of an Early Palliative Care Intervention for Advanced Heart Failure Patients.

    • Rachel Wells, James Nicholas Dionne-Odom, Andres Azuero, Harleah Buck, Deborah Ejem, Kathryn L Burgio, Macy L Stockdill, Rodney Tucker, Salpy V Pamboukian, Jose Tallaj, Sally Engler, Konda Keebler, Sheri Tims, Raegan Durant, Keith M Swetz, and Marie Bakitas.
    • School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: raduncan@uab.edu.
    • J Pain Symptom Manage. 2021 Sep 1; 62 (3): 471-481.

    ContextResearch priority guidelines highlight the need for examining the "dose" components of palliative care (PC) interventions, such as intervention adherence and completion rates, that contribute to optimal outcomes.ObjectivesExamine the "dose" effect of PC intervention completion vs. noncompletion on quality of life (QoL) and healthcare use in patients with advanced heart failure (HF) over 32 weeks.MethodsSecondary analysis of the ENABLE CHF-PC intervention trial for patients with New York Heart Association (NYHA) Class III/IV HF. "Completers" defined as completing a single, in-person outpatient palliative care consultation (OPCC) plus 6 weekly, PC nurse coach-led telehealth sessions. "Non-completers" were defined as either not attending the OPCC or completing <6 telehealth sessions. Outcome variables were QoL and healthcare resource use (hospital days; emergency department visits). Mixed models were used to model dose effects for "completers" vs "noncompleters" over 32 weeks.ResultsOf 208 intervention group participants, 81 (38.9%) were classified as "completers" with a mean age of 64.6 years; 72.8% were urban-dwelling; 92.5% had NYHA Class III HF. 'Completers' vs. "non-completers"" groups were well-balanced at baseline; however "noncompleters" did report higher anxiety (6.0 vs 7.0, P < 0.05, d = 0.28). Moderate, clinically significant, improved QoL differences were found at 16 weeks in "completers" vs. "non-completers" (between-group difference: -9.71 (3.18), d = 0.47, P = 0.002) but not healthcare use.ConclusionHigher intervention completion rates of an early PC intervention was associated with QoL improvements in patients with advanced HF. Future work should focus on identifying the most efficacious "dose" of intervention components and increasing adherence to them.Trial RegistrationClinicalTrials.gov Identifier: NCT02505425.Copyright © 2021 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

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