• Arab J Gastroenterol · Mar 2016

    Case Reports

    Khat-induced liver injuries: A report of two cases.

    • Omkolsoum M Alhaddad, Maha M Elsabaawy, Eman A Rewisha, Tary A Salman, Mohamed A S Kohla, Nermine A Ehsan, and Imam A Waked.
    • Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El Kom 234511, Egypt. Electronic address: dromkolsoum@yahoo.com.
    • Arab J Gastroenterol. 2016 Mar 1; 17 (1): 45-8.

    AbstractKhat is consumed for recreational purposes in many countries, including Yemen, where >50% of adults chew khat leaves regularly. A wide spectrum of khat-induced liver injuries has been reported in the literature. Herein, we report two patients with khat-induced liver injury. Both patients clinically presented with acute hepatitis, one of whom showed radiological evidence of hepatic outflow obstruction. Based on the histological tests, both patients had acute hepatitis, which indicated drug-induced liver injury (DILI) on a background of chronic hepatitis and portal fibrosis; of the two, one presented with symptoms of immune-mediated liver injury. Copyright © 2016 Arab Journal of Gastroenterology. Published by Elsevier B.V. All rights reserved.

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