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- Wolf-Henning Boehncke.
- Department of Dermatology and Venereology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, Genève 14 CH - 1211, Switzerland; Department of Pathology and Immunology, University of Geneva, Rue Michel-Servet 7, Geneva CH - 1206, Switzerland. Electronic address: wolf-henning.boehncke@hcuge.ch.
- Rheum. Dis. Clin. North Am. 2015 Nov 1; 41 (4): 665-75.
AbstractPsoriasis is a common, chronic inflammatory skin disease most often appearing in the form of well-demarcated, scaly plaques. These lesions highlight the fundamental processes underlying its pathogenesis, namely, inflammation and epidermal hyperproliferation. Both phenomena are considered consequences of an intimate interplay between the innate and the adaptive immune system. This concept is supported by results of genetic studies, pointing toward the signaling pathways of nuclear factor-κB, interferon-γ, and interleukin (IL)-23 as well as antigen presentation as central axes of the psoriatic inflammation. Efficacy of biologics targeting tumor necrosis factor-α, IL-23, or IL-17 provides further evidence in favor of this model. Copyright © 2015 Elsevier Inc. All rights reserved.
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