• Jin-Cheng Wu, Zhao-Hui Liu, Xiaomei Ding, and Rui-Sheng Ke.
• Department of General Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 361001, Fujian, China.
• Ir J Med Sci. 2022 Feb 1; 191 (1): 139-145.

BackgroundGastric cancer is a common malignant tumor with an increasing death rate. MicroRNA can serve as a promising biomarker for the progression and prognosis of various cancers.AimsThe clinical significance and biological function of miR-3178 in gastric cancer was assessed in this study.MethodsA total of 117 paired tissues were collected from gastric cancer patients. Quantitative real-time polymerase chain reaction was used to detect the expression of miR-3178 in gastric cancer tissues and cells. The association between miR-3178 expression and the clinicopathological features of patients were analyzed by χ2 test. Kaplan-Meier analysis and Cox regression were employed to investigate the prognostic value of miR-3178. Finally, the effect of miR-3178 on the cellular process of gastric cancer was investigated by CCK-8 and transwell assay.ResultsmiR-3178 was downregulated in gastric cancer tissues and cells, which showed a significant association with the TNM stage and lymph node metastasis of patients and a poor prognosis. MiR-3178 and TNM stage were considered as two independent prognostic factors for gastric cancer. Furthermore, the downregulation of miR-3178 promoted cell proliferation, migration, and invasion of gastric cancer by regulating Notch1.ConclusionmiR-3178 may be involved in the progression of gastric cancer, which provides new insights into the treatment of gastric cancer.© 2021. Royal Academy of Medicine in Ireland.

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