-
Review
There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia.
- Joseph Williamson, Louisa Black, Anna Black, Gouri Koduri, and Clive Kelly.
- Sheffield University, Sheffield, UK.
- Ir J Med Sci. 2022 Feb 1; 191 (1): 151-5.
IntroductionThere is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both.MethodsThis review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders.ResultsThe therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this.DiscussionWe propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other.© 2021. Royal Academy of Medicine in Ireland.
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