• Erol Oksuz, Fatih Ersay Deniz, Ozgur Gunal, Ozgur Demir, Sener Barut, Fatma Markoc, and Unal Erkorkmaz.
• Department of Neurosurgery, Gaziosmanpasa University, Tokat, Turkey. eroloksuz@yahoo.com.
• Eur Spine J. 2016 Apr 1; 25 (4): 1006-11.

BackgroundSeveral methods have been used to reduce the infection rate in spinal surgeries with instrumentation.PurposeWhich method is the most effective for preventing postoperative infection?Study DesignBasic science, animal model.ObjectiveIn the present study, the efficiency of antibiotic prophylaxis, silver-plated screws, and local rifamycin application to the surgical site was investigated in an experimental animal model. Staphylococcus aureus was used as the pathogen.MethodsFifty 6-month-old female Wistar albino rats were used. The animals were randomly numbered and divided into five groups of ten rats each (Group 1, control group; Group 2, titanium screw and S. aureus inoculation; Group 3, titanium screw, 0.1 ml rifamycin application to the surgical area, and bacterial inoculation; Group 4, titanium screw, single preoperative dose of IM cefazolin, and bacterial inoculation; Group 5, silver-plated screw and bacterial inoculation). Titanium micro-screws were placed into the pedicles. The control group received a sterile isotonic solution, and the other four groups received bacterial suspensions containing S. aureus. The animals were killed 15 days later.ResultsIntensive S. aureus growth was observed in all tissue and screw samples from Group 2. The results for Group 3 were similar to those for Group 1, no growth was observed in the screw cultures. Intensive growth was observed in the five screw samples in Group 4 and in the eight samples in Group 5.ConclusionOur study suggests that rifamycin application to the surgical area in spinal operations with instrumentation is an effective method to prevent S. aureus infections.

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