• Epigenomics · Jan 2015

    DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

    • Leonidas Chouliaras, Gunter Kenis, Pieter Jelle Visser, Philip Scheltens, Magda Tsolaki, Roy W Jones, Patrick G Kehoe, Caroline Graff, Nicola G Girtler, Åsa K Wallin, Marcel Olde Rikkert, Luiza Spiru, Lyzel S Elias-Sonnenschein, Inez H G B Ramakers, Ehsan Pishva, Jim van Os, Harry W M Steinbusch, Frans R J Verhey, Daniel L A van den Hove, and Bart P F Rutten.
    • Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
    • Epigenomics. 2015 Jan 1; 7 (4): 533-7.

    AbstractEpigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.

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