• Daipayan Guha, Tim-Rasmus Kiehl, Timo Krings, and Taufik A Valiante.
• Faculty of Medicine, University of Toronto, Department of Pathology, University Health Network, Toronto Western Hospital Research Institute, Toronto, Ontario, Canada. deep.guha@mail.utoronto.ca
• J. Neurosurg. 2012 Jul 1; 117 (1): 136-40.

AbstractSchwannomas of the brain parenchyma are extremely rare, occurring mostly in children and young adults. Fewer than 50 cases have been reported in the English-language literature. Isolated temporal lobe epilepsy is a rare presentation of intracerebral schwannomas, with only 2 reported cases. The authors present the case of a 51-year-old woman with a 4-year history of medication-refractory seizures, which were localized on electroencephalography to the right temporal lobe. Magnetic resonance imaging identified a mildly space-occupying, T2 hyperintense, and inhomogeneously enhancing mass in her left mesial temporal lobe. Histological, immunohistochemical, and electron microscopy examinations of the surgical specimen established a diagnosis of intracerebral schwannoma. Accurate diagnosis of intracerebral schwannomas is essential, particularly in younger patients, given the lesions' nature, amenity to resection, favorable long-term prognosis, and broad radiological differential. The etiology of these lesions remains unknown, and multiple proposed theories are reviewed.

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