• Prashanth J Rao, Ajanthan Loganathan, Vivian Yeung, and Ralph J Mobbs.
• *Neurospine Clinic, Randwick, Sydney, New South Wales, Australia; ‡Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia; §University of New South Wales, Sydney, Australia.
• Neurosurgery. 2015 Jan 1; 76 (1): 7-23; discussion 23-4.

BackgroundThere is limited information on clinical outcomes after anterior lumbar interbody fusion (ALIF) based on the indications for surgery.ObjectiveTo compare the clinical and radiological outcomes of ALIF for each surgical indication.MethodsThis prospective clinical study included 125 patients who underwent ALIF over a 2-year period. The patients were evaluated preoperatively and postoperatively. Outcome measures included the Short Form-12, Oswestry Disability Index, Visual Analog Scale, and Patient Satisfaction Index.ResultsAfter a mean follow-up of 20 months, the clinical condition of the patients was significantly better than their preoperative status across all indications. A total of 108 patients had a Patient Satisfaction Index score of 1 or 2, indicating a successful clinical outcome in 86%. Patients with degenerative disk disease (with and without radiculopathy), spondylolisthesis, and scoliosis had the best clinical response to ALIF, with statistically significant improvement in the Short Form-12, Oswestry Disability Index, and Visual Analog Scale. Failed posterior fusion and adjacent segment disease showed statistically significant improvement in all of these clinical outcome scores, although the mean changes in the Short Form-12 Mental Component Summary, Oswestry Disability Index, and Visual Analog Scale (back pain) were lower. The overall radiological fusion rate was 94.4%. Superior radiological outcomes (fusion >90%) were observed in patients with degenerative disk disease (with and without radiculopathy), spondylolisthesis, and failed posterior fusion, whereas in adjacent segment disease, it was 80%.ConclusionALIF is an effective treatment for degenerative disk disease (with and without radiculopathy) and spondylolisthesis. Although results were promising for scoliosis, failed posterior fusion, and adjacent segment disease, further studies are necessary to establish the effectiveness of ALIF in these conditions.

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