• Med. Clin. North Am. · Mar 2021

    Review

    Management of Knee Osteoarthritis: What Internists Need to Know.

    • Joel A Block and Dmitriy Cherny.
    • Division of Rheumatology, Rush University Medical Center, 1611 West Harrison Street, Suite 510, Chicago, IL 60612, USA. Electronic address: jblock@rush.edu.
    • Med. Clin. North Am. 2021 Mar 1; 105 (2): 367-385.

    AbstractKnee osteoarthritis (OA) is a common and morbid condition. No disease-modifying therapies exist; hence the goals of current treatment are to palliate pain and to retain function. OA is significantly influenced by the placebo effect. Nonpharmacologic interventions are essential and have been shown to improve outcomes. Canes, unloading braces, and therapeutic heating/cooling may be valuable. Pharmacotherapy options include topical and oral nonsteroidal anti-inflammatory drugs, duloxetine, and periodic intra-articular glucocorticoids and hyaluronans. Opioids, intra-articular stem cells, and platelet-rich plasma are not recommended. Novel targets such as nerve growth factor are under investigation and may be approved soon for OA pain.Copyright © 2020 Elsevier Inc. All rights reserved.

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