• Br J Anaesth · Dec 1985

    Comparative Study

    Antagonism of the muscarinic effects of edrophonium with atropine or glycopyrrolate. A comparative study.

    • R K Mirakhur.
    • Br J Anaesth. 1985 Dec 1; 57 (12): 1213-6.

    AbstractThe efficacy of atropine or glycopyrrolate in doses of 10 or 20 micrograms kg-1 and 5 or 10 micrograms kg-1, respectively, has been compared when administered to block the muscarinic effects of edrophonium 0.5 mg kg-1 administered for the reversal of neuromuscular blockade. Both doses of atropine and the higher dose of glycopyrrolate prevented any edrophonium-induced decreases in heart rate; glycopyrrolate at this dose was associated with tachycardia. Atropine and edrophonium could be safely administered together in a mixture. The control of oropharyngeal secretions was adequate even with the lower doses of both anticholinergic agents. Atropine 10 micrograms kg-1 appears to be a better anticholinergic agent for use with edrophonium.

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