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- Andrea Tassi, Stefano Gitto, Chiara Piras, Carmela Cursaro, Tatiana Alicandro, Marzia Margotti, Marco Rivi, and Pietro Andreone.
- Division of Internal Medicine, Department of Medical and Surgical Sciences, Maternal-Infantile and Adult, University of Modena and Reggio Emilia, Modena, Italy.
- Minerva Med. 2021 Apr 1; 112 (2): 238-245.
AbstractChronic Hepatitis C is associated with many extrahepatic manifestations. Central nervous system is frequently involved, but the pathophysiological mechanisms are not fully understood. Local and systemic inflammation, ischemia, immune-mediated phenomena have been described in this context. Clinical manifestations include cognitive alterations, stroke, depression and demyelinating phenomena. It is unclear if cognitive deficits can be improved or resolved with viral eradication and to understand this, could have important therapeutical implications.
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