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Current diabetes reports · Jun 2019
ReviewHurdles to Generating Human Islets in Animals via Blastocyst Complementation.
- Tomoyuki Yamaguchi.
- Division of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. tomoyama@ims.u-tokyo.ac.jp.
- Curr. Diab. Rep. 2019 Jun 24; 19 (8): 45.
Purpose Of ReviewTo clarify the hurdles to generation of human islets via blastocyst complementation and to identify techniques to overcome them.Recent FindingsBlastocyst complementation is a promising method for generating functional islets from pluripotent stem cells which are identical to in vivo islets. Studies have reported successful generation of mouse pancreas in rats and rat pancreas in mice via interspecies blastocyst complementation and have shown the possibility for generation of human organs in xenogeneic animals. However, there remain hurdles to generating human islets in animals. The major hurdles to generating human islets include difficulty in engineering human-animal chimeras due to the cellular status of human pluripotent stem cells, immunological rejection of donor tissue in xenogeneic animals, and ethical concerns.
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