• Eur. J. Clin. Invest. · Oct 2021

    The role of sperm and oocyte in fetal programming: Is Lamarck making a comeback?

    • Renata Santos Tavares and João Ramalho-Santos.
    • CNC-Center for Neuroscience and Cell Biology, CIBB, Azinhaga de Santa Comba, Polo 3, University of Coimbra, Coimbra, Portugal.
    • Eur. J. Clin. Invest. 2021 Oct 1; 51 (10): e13521.

    AbstractCompelling evidence has shown that parental experiences and age at conception may potentially shape the future health of the next generation(s). Certain factors may affect both the female and, strikingly, the male gametes potentially causing the transmission of acquired traits, which was strongly defended by Jean-Baptiste Lamarck. Neurodevelopmental psychiatric disorders, trinucleotide repeat-associated diseases, cardiovascular pathologies, diabetes, obesity and cancer in the offspring, among others, have now been associated with events occurring at the preconception level. The potential implications of a (trans)generational inheritance of parental disease and exposure effects should be taken into account in counselling and public policy. Further research into how exactly gametes apparently deliver more than DNA to a new generation is warranted.© 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…