• Haewon Lee, Jennifer A Punt, David C Miller, Ameet Nagpal, Clark C Smith, Yusef Sayeed, Jaymin Patel, Milan P Stojanovic, Adrian Popescu, Zachary L McCormick, and Spine Intervention Society’s Patient Safety Committee.
• University of California, San Diego, Department of Orthopedic Surgery, San Diego, California, USA.
• Pain Med. 2021 Apr 20; 22 (4): 9941000994-1000.

MythCorticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19).FactThere is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine.However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible.© The Author(s) 2020/2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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