• N. Engl. J. Med. · Apr 2021

    Letter

    Neutralizing Activity of BNT162b2-Elicited Serum.

    The Pfizer–BioNTech COVID-19 vaccine was 91% effective in preventing infection with SARS-CoV-2 in phase 3 trials.

    pearl
    • Yang Liu, Jianying Liu, Hongjie Xia, Xianwen Zhang, Camila R Fontes-Garfias, Kena A Swanson, Hui Cai, Ritu Sarkar, Wei Chen, Mark Cutler, David Cooper, Scott C Weaver, Alexander Muik, Ugur Sahin, Kathrin U Jansen, Xuping Xie, Philip R Dormitzer, and Pei-Yong Shi.
    • University of Texas Medical Branch, Galveston, TX.
    • N. Engl. J. Med. 2021 Apr 15; 384 (15): 146614681466-1468.

    no abstract available

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    This article appears in the collection: COVID-19 and mRNA Vaccines.

    Notes

    pearl
    1

    The Pfizer–BioNTech COVID-19 vaccine was 91% effective in preventing infection with SARS-CoV-2 in phase 3 trials.

    Daniel Jolley  Daniel Jolley
    summary
    1

    Pfizer and BioNTech reported that phase 3 trials of their mRNA SARS-COV-2 vaccine showed:

    • Analysis of 927 confirmed symptomatic cases of COVID-19 demonstrates BNT162b2 is highly effective with 91.3% vaccine efficacy observed against COVID-19, measured seven days through up to six months after the second dose.
    • Vaccine was 100% effective in preventing severe disease as defined by the U.S. Centers for Disease Control and Prevention and 95.3% effective in preventing severe disease as defined by the U.S. Food and Drug Administration.
    • Vaccine was 100% effective in preventing COVID-19 cases in South Africa, where the B.1.351 lineage is prevalent.
    • Vaccine safety now evaluated in more than 44,000 participants 16 years of age and older, with more than 12,000 vaccinated participants having at least six months follow-up after their second dose.
    Daniel Jolley  Daniel Jolley
     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…