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The Pfizer–BioNTech COVID-19 vaccine was 91% effective in preventing infection with SARS-CoV-2 in phase 3 trials.
pearl- Yang Liu, Jianying Liu, Hongjie Xia, Xianwen Zhang, Camila R Fontes-Garfias, Kena A Swanson, Hui Cai, Ritu Sarkar, Wei Chen, Mark Cutler, David Cooper, Scott C Weaver, Alexander Muik, Ugur Sahin, Kathrin U Jansen, Xuping Xie, Philip R Dormitzer, and Pei-Yong Shi.
- University of Texas Medical Branch, Galveston, TX.
- N. Engl. J. Med. 2021 Apr 15; 384 (15): 146614681466-1468.
no abstract available
This article appears in the collection: COVID-19 and mRNA Vaccines.
Notes
Pfizer and BioNTech reported that phase 3 trials of their mRNA SARS-COV-2 vaccine showed:
- Analysis of 927 confirmed symptomatic cases of COVID-19 demonstrates BNT162b2 is highly effective with 91.3% vaccine efficacy observed against COVID-19, measured seven days through up to six months after the second dose.
- Vaccine was 100% effective in preventing severe disease as defined by the U.S. Centers for Disease Control and Prevention and 95.3% effective in preventing severe disease as defined by the U.S. Food and Drug Administration.
- Vaccine was 100% effective in preventing COVID-19 cases in South Africa, where the B.1.351 lineage is prevalent.
- Vaccine safety now evaluated in more than 44,000 participants 16 years of age and older, with more than 12,000 vaccinated participants having at least six months follow-up after their second dose.
Daniel Jolley
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