• Ann. N. Y. Acad. Sci. · Jan 2009

    SNAP-25 in neuropsychiatric disorders.

    • Irene Corradini, Claudia Verderio, Mariaelvina Sala, Michael C Wilson, and Michela Matteoli.
    • Department of Medical Pharmacology, University of Milan, Milano, Italy.
    • Ann. N. Y. Acad. Sci. 2009 Jan 1; 1152: 93-9.

    AbstractSNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

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