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- Jian Han, Jiazhi Sun, Guixin Zhang, and Hailong Chen.
- General Surgery Department, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
- Int J Med Sci. 2021 Jan 1; 18 (2): 406418406-418.
AbstractPneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is spreading globally. There have been strenuous efforts to reveal the mechanisms that the host defends itself against invasion by this virus. The immune system could play a crucial role in virus infection. Dendritic cell as sentinel of the immune system plays an irreplaceable role. Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. In this review, the characteristics of coronavirus are described briefly. We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. Basis of treatment based dendritic cells to combat coronavirus infections is summarized. Finally, we propose that the combination of DCs based vaccine and other therapy is worth further study.© The author(s).
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