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- Hui Li, Hui-Min Zhang, Li-Juan Fan, Han-Han Li, Zi-Tan Peng, Jia-Peng Li, Xiao-Yu Zhang, Yuan Xiang, Chao-Jiang Gu, Xing-Hua Liao, Li Wang, and Tong-Cun Zhang.
- College of Life Sciences and Health, School of Resource and Environmental Engineering, Wuhan University of Science and Technology, Hubei, 430081, P.R.China.
- Int J Med Sci. 2021 Jan 1; 18 (4): 964974964-974.
AbstractEndothelial cell proliferation disorder caused by vascular injury seems to be one of the causes of atherosclerosis, which is the pathological basis of coronary heart disease. The role of STAT3 in the regulation of microRNAs and endothelial dysfunction in atherosclerosis is unclear. STAT3 can be activated by cytokine IL-6 and up regulate the expression of CX3CL1. In addition, microRNA-15a-5p (miR-15a-5p) inhibited the transcription of CX3CL1, the proliferation of vascular endothelial cells and the proliferation of STAT3 regulated vascular endothelial cells. STAT3 positively regulates the expression of CX3CL1, and then down-regulates the inhibition of CX3CL1 by over-expression of miR-15a-5p, thus forming an elimination feedback loop to control the proliferation of HUVECs and affect the progression of atherosclerosis. In conclusion, miR-15a-5p may be the therapeutic target of the pathological basis of coronary atherosclerosis.© The author(s).
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