• Brain research · Aug 2001

    Leukaemia inhibitory factor abrogates Paclitaxel-induced axonal atrophy in the Wistar rat.

    • Kilpatrick T J TJ The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia., S Phan, K Reardon, E C Lopes, and S S Cheema.
    • The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.
    • Brain Res. 2001 Aug 24; 911 (2): 163-7.

    AbstractA prominent side effect of Paclitaxel chemotherapy is sensorimotor peripheral neuropathy. Leukaemia inhibitory factor (LIF) supports the survival and regrowth of axotomised sensory and motor neurons and we therefore investigated if systemically administered LIF abrogated Paclitaxel-induced neuropathy. We found that whereas animals administered Paclitaxel alone exhibited a significant decrease in the percentage of large myelinated axons, this reduction was prevented by the co-administration of LIF.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…