• Leukemia research · Aug 2010

    Case Reports

    Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.

    • Zhenjun Lou, Cheng Cheng Zhang, Carlos A Tirado, Tamara Slone, Junke Zheng, Charles M Zaremba, Dwight Oliver, and Weina Chen.
    • Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9073, USA.
    • Leuk. Res. 2010 Aug 1; 34 (8): 1107-9.

    AbstractWe report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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