• Tohru Hoshida.
• National Hospital Organization Nara Medical Center, Shichi-jyo, Nara-city, Nara 630-8053, Japan.
• Brain Nerve. 2011 Apr 1; 63 (4): 313-20.

AbstractSurgery is a better treatment option than prolonged medical therapy for patients with temporal lobe epilepsy. Randomized trials on surgery for epilepsy are feasible and appear to yield precise estimates of the effects of surgical treatment. This study includes 56 patients who underwent anterior temporal lobectomy with a mean follow-up of 11.3 years. The probability of achieving complete seizure freedom at 5 and 10 years is 73% and 69%, respectively. Patients who had discrete abnormalities (i.e., tumors, gliosis, or hippocampal sclerosis) before surgery had a significantly higher probability of achieving seizure freedom than did patients without obvious abnormalities. Of the 32 patients, 30 (94%) had the same seizure status as that after surgery at the-10 year follow-up, and 2 (6%) had recurrent seizures. Of the seizure-free patients, 16 (29%) had ceased taking antiepileptic drugs (AEDs) at the 5-year follow-up, and 8 (25%) had ceased taking the drugs at the 10-year follow-up. In this paper, the evolution of the understanding of temporal lobe epilepsy surgery has been discussed. The efficacy of temporal lobe epilepsy surgery remains controversial with regard to the chois of resection method that would provide the best results for seizure freedom and cognitive function. The seizure outcomes obtained after selective amygdalohippocampectomy were found to be similar to those obtained after temporal lobe resection in several studies, and there is considerable evidence for indicating that the neuropsychological outcomes obtained after selective amygdalohippocampectomy are better than those obtained after temporal lobe resection. No significant relationships were found between objective indices of change and subjective ratings for postoperative memory function. A new surgical method based on multiple subpial transections for the hippocampus was developed in 2006. It remains unclear whether mesial resection involving a larger area leads to better seizure outcomes.

21 keywords...

hide…