• J Psychoactive Drugs · Apr 2001

    Case Reports

    Gamma hydroxybutyrate (GHB) and gamma butyrolactone (GBL) withdrawal: five case studies.

    • C H McDaniel and K A Miotto.
    • ULCA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California 90024, USA.
    • J Psychoactive Drugs. 2001 Apr 1; 33 (2): 143-9.

    AbstractThere is little medical information available about gamma-hydroxybutyrate (GHB) or gamma-butyrolactone (GBL) dependence or withdrawal. In this study the authors treated and reviewed multiple cases of GHB and GBL withdrawal in high-dose users. Five patients during nine hospitalizations were treated for GHB or GBL withdrawal. The authors describe a spectrum of GHB or GBL withdrawal from mild to severe and discuss medications used for treatment. They conclude that patients with GHB or GBL withdrawal may present with agitated psychosis, delirium, and autonomic instability. In this sample, relapse to GHB or GBL use occurred soon after treatment of withdrawal.

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