• Daqian Gao, Xinqin Zhou, ZhenHua Gao, Xincui Shi, Zongliang Wang, Yu Wang, and Peibiao Zhang.
• Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Research and Development Center for Wound Repair Materials and Regenerative Medicine, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences-Huibo Medical, Nanyang 473000, PR China; College of Material Science and Engineering, Northeast Forestry University, Harbin 150040, PR China.
• J Pharm Sci. 2018 Sep 1; 107 (9): 2377-2384.

AbstractIn this study, we prepared a series of silver sulfadiazine (AgSD)-loaded polyvinyl alcohol (PVA) hydrogels via electron beam (e-beam) irradiation. Our objective was to explore the influence of e-beam irradiation on the chemical structure and crystallinity of AgSD and the antibacterial properties of AgSD/PVA hydrogels. Prior to irradiation, we mixed AgSD in PVA solution in 2 forms, either suspended in water (WS) or dissolved in ammonia solution (AS). We noted that nano silver was released from AgSD/PVA-AS hydrogels immersed in deionized water, while it would not happen in AgSD/PVA-WS hydrogels. Both kinds of AgSD/PVA hydrogels exhibited good antibacterial activities against gram-negative Escherichia coli and gram-positive Staphylococcus aureus. And their antibacterial activity was not obviously affected by different dosages of e-beam irradiation. Moreover, the antibacterial activity of the AgSD/PVA-WS hydrogels was stronger than that of AgSD/PVA-AS. Accordingly, the cell cytotoxicity of the AgSD/PVA-WS hydrogels was higher than that of AgSD/PVA-AS. Our study results reveal that e-beam irradiation of PVA solution with dispersed AgSD is a simple and efficient way to prepare AgSD/PVA hydrogels, which might be an ideal antibacterial wound dressing.Copyright © 2018. Published by Elsevier Inc.

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