• Clin. Infect. Dis. · Sep 2005

    Case Reports

    Successful treatment of Aspergillus prosthetic valve endocarditis with oral voriconazole.

    • Lisa J Reis, Todd D Barton, Alberto Pochettino, Omaida Velazquez, Michael McGarvey, Bonnie Milas, Annette Reboli, and Mindy G Schuster.
    • Hospital of The University of Pennsylvania, Philadelphia, PA, USA.
    • Clin. Infect. Dis. 2005 Sep 1; 41 (5): 752-3.

    AbstractAspergillus endocarditis is very difficult to cure, even with aggressive surgical debridement and antifungal therapy. Patients with embolic involvement of the central nervous system have an extremely poor prognosis. We describe a patient with prosthetic valve endocarditis due to Aspergillus fumigatus who developed emboli in the brain, eye, and lower extremities. With aggressive surgical debridement of involved sites, aortic valve and root replacement, and long-term therapy with oral voriconazole, he remains without any evidence of infection 2 years later.

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