• Mohsin Sheraz Mughal, Ikwinder Preet Kaur, Ali R Jaffery, Denise L Dalmacion, Chang Wang, Sai Koyoda, Violet E Kramer, Chandler D Patton, Sharon Weiner, Margaret H Eng, and Kenneth M Granet.
• Monmouth Medical Center, An Affiliate of Robert Wood Johnson/Barnabas Health Care System, 300 2nd Avenue, Long Branch, NJ, 07740, USA.
• Respir Med. 2020 Oct 1; 172: 106130.

IntroductionPatients with severe COVID-19 can develop ventilator-dependent acute hypoxic respiratory failure (VDAHRF), which is associated with a higher mortality rate. We evaluated the clinical course of hospitalized COVID-19 patients and compared them with the patients who received invasive mechanical ventilation. Characteristics of intubated patients who were successfully weaned from the ventilator were compared with the patients who failed to be extubated or died in the hospital.ObjectiveTo investigate the clinical course of hospitalized COVID-19 patients, and assess the possible predictors of the disease severity leading to VDAHRF.MethodsThis is a single-center, retrospective study. The first 129 patients (18 years or older) with COVID-19 admitted to Monmouth Medical Center from March 1st to April 25th, 2020 were included.ResultsOut of 129 patients, 23.25% (n = 30) required invasive mechanical ventilation, and of those, six patients were successfully weaned from the ventilator. Multivariable logistic regression analysis showed increased odds of intubation associated with hypoxemia (odds ratio 17.23, 95% CI 5.206-57.088; p < 0.0001), elevated d-dimer by one unit mg/L of FEU (odds ratio 1.515, 95% CI 5.206-57.088; p = 0.0430) and elevated ferritin by one unit ng/ml (odds ratio 1.001, 95% CI 1.000-1.001, p = 0.0051) on admission, adjusted for other covariates.ConclusionsPatients who required invasive mechanical ventilation were more likely to have older age, male gender, coronary artery disease, diabetes, and obesity. The patients who were successfully weaned from the ventilator were more likely to be younger in age, and none of them had heart failure or CAD.Copyright © 2020 Elsevier Ltd. All rights reserved.

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