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- Florian Klein, Lilian Nogueira, Yoshiaki Nishimura, Ganesh Phad, Anthony P West, Ariel Halper-Stromberg, Joshua A Horwitz, Anna Gazumyan, Cassie Liu, Thomas R Eisenreich, Clara Lehmann, Gerd Fätkenheuer, Constance Williams, Masashi Shingai, Malcolm A Martin, Pamela J Bjorkman, Michael S Seaman, Susan Zolla-Pazner, Gunilla B Karlsson Hedestam, and Michel C Nussenzweig.
- Laboratory of Molecular Immunology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 fklein@rockefeller.edu.
- J. Exp. Med. 2014 Nov 17; 211 (12): 2361-72.
AbstractAntibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian-human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to the control of viremia. Here, we investigate how the autologous antibody response in intact hosts can contribute to the success of immunotherapy. We find that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively administered bNAbs by preventing the emergence of bNAb viral escape variants. © 2014 Klein et al.
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