• Immunotherapy · Jan 2014

    Review

    Broadly neutralizing antibodies and the promise of universal vaccines: where are we now?

    • Kathleen L Hefferon.
    • University of Toronto, Toronto, Ontario, Canada and Cornell University, Ithaca, NY, USA. klh22@cornell.edu.
    • Immunotherapy. 2014 Jan 1; 6 (1): 51-7.

    AbstractRecent research has provided strong support for the utility of broadly neutralizing antibodies generated against viruses, which inherently possess a high degree of antigenic variability (such as influenza virus or HIV) as a feasible means to prevent infection. Many of these antibodies share the ability to bind to highly conserved regions within the stem of the virus 'spike' or surface glycoprotein, in such a way that they interfere with virus entry, including membrane fusion. As a result, broadly neutralizing antibodies could be supplied to patients as a form of passive immunotherapy, as well as play a role in the design of new 'universal' vaccines and antiviral agents. The following article describes the most recent innovations in this exciting field.

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