• Xiao-long Wang, Ou Liu, Yan-wen Qin, Hong-jia Zhang, and Yi Lv.
• 1] Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi-an Jiaotong University, Xi-an 710000, China [2] Department of Cardiovascular Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China.
• Acta Pharmacol. Sin. 2014 Mar 1; 35 (3): 351-5.

AimThoracic aortic dissection (TAD) is the most common life-threatening disorder, and a shifted balance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is involved in TAD pathogenesis. The aim of this study was to evaluate the association of 4 single-nucleotide polymorphisms (SNPs) in MMP-9 and TIMP-3 genes with TAD risk in Chinese Han population.MethodsA total of 206 Chinese patients with TAD and 180 controls were included in this study. Four SNPs (rs3918249, rs2274756, rs9609643 and rs8136803) were genotyped using high-throughput MALDI-TOF mass spectrometry. Allele and genotype association analyses were conducted using PLINK.ResultsAll the 4 SNPs resulted in Hardy-Weinberg equilibrium in patients and controls. The G allele frequency for the MMP-9 SNP rs2274756 was significantly higher in female TAD patients than in female controls (P=0.0099). Moreover, after adjusting for traditional cardiovascular risk factors (sex, age, hypertension, dyslipidemia, diabetes and smoking habit), the rs2274756 polymorphism (odds ratio: 0.30; 95% confidence interval: 0.11 to 0.79, P=0.015) resulted in an independent susceptibility factor for TAD in females. No associations were found between the other SNPs and TAD.ConclusionThe results provide strong evidence for an association between MMP-9 SNP rs2274756 and female TAD risk in Chinese Han population.

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