• Yuta Aoki, Kiyoshi Shakunaga, Takehisa Asahi, Rika Sasaki, Junichi Murahana, Noboru Hatakeyama, and Mitsuaki Yamazaki.
• Department of Anesthesiology, Faculty of Medicine, University of Toyama, Toyama 930-0194.
• Masui. 2008 Apr 1; 57 (4): 447-9.

AbstractStiff-person syndrome is a rare disease characterized by muscle rigidity and painful spasms in the axial and limb muscles. The authors reported here a case of an axilally lymphadenectomy in a 46-year-old woman with stiff-person syndrome. With train of four ratio (TOFR) monitoring at the ulnar nerve, general anesthesia was induced and maintained with fentanyl, vecuronium and propofol with target controlled infusion. A TOFR, BIS monitor and invasive arterial pressure monitoring were employed. During the operation, there was no muscle rigidity and spasm. Ten minutes after the operation, she was fully awake and train of four ratio recovered to 95%, and extubated uneventfully. We chose propofol, because of previous reports about prolonged hypotonicity by interaction of baclofen and isoflurane. Preoperative good symptom control, choice of total intravenous anesthesia (TIVA), and application of the electrical nerve stimulator prevented postoperative hypotonia and resulted in safe anesthetic management.

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