• Cheng-Peng Sun, Zi-Li Jia, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Chao Wang, Bao-Jing Zhang, Wen-Yu Zhao, and Xiao-Chi Ma.
• Dalian Key Laboratory of Metabolic Target, Characterization and Traditional Chinese, Medicine Intervention, College of Pharmacy, Institute of Integrative Medicine, Dalian, Medical University, Dalian, P. R. China.
• Am. J. Chin. Med. 2021 Jan 1; 49 (2): 315-358.

AbstractAs a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary metabolites, including several known natural products that were isolated for the first time from the genus Inula. Most of them exhibited potential bioactivities in various diseases. The review aimed to summarize the advance of recent researches (2010-2020) on phytochemical constituents, biosynthesis, and pharmacological properties of the genus Inula for providing a scientific basis and supporting its application and exploitation for new drug development.

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