• Annals of surgery · Jan 2023

    Cost-Effectiveness of Diagnostic Tools to Establish the Presence of Peripheral Arterial Disease in People with Diabetes.

    • Pasha Normahani, David M Epstein, Alessio Gaggero, Alun H Davies, Viknesh Sounderajah, and Usman Jaffer.
    • Imperial Vascular Unit, Imperial College NHS Healthcare Trust, London, United Kingdom.
    • Ann. Surg. 2023 Jan 1; 277 (1): e184e191e184-e191.

    ObjectiveTo evaluate the cost-effectiveness of point-of-care duplex ultrasound (PAD-scan) and other bedside tests for the diagnosis of peripheral arterial disease (PAD) in people with diabetes.BackgroundPAD is a risk factor for cardiovascular disease, diabetic foot ulceration (DFU), and amputation in diabetic patients. Diagnosis enables optimization of therapies to manage these risks. PAD-scan can be performed by frontline staff and has been shown to be the most accurate bedside test. However, its cost-effectiveness has not been investigated.MethodsA Markov model was constructed to estimate the health outcomes and costs over 5 years of different testing strategies applied to a cohort of diabetic patients. Bedside tests investigated were PAD-scan, ankle-brachial pressure index, toe-brachial pressure index, audible and visual Doppler, transcutaneous pressure of oxygen, and pulse palpation. Health outcomes were incidence of new DFU, major cardiovascular events, amputation, death, and DFU healing rates. Sensitivity analyses were performed.ResultsPAD-scan was the most cost-effective bedside test with an incremental cost-effectiveness ratio of £11,391/quality-adjusted life years. PADscan had the highest probability (78.7%) of having the greatest net benefit at a willingness to pay threshold of £20,000 per quality-adjusted life years. It reduced the number of amputations by 24% and the number of cardiovascular deaths by 10% over 5 years, compared to toe-brachial pressure index (next best alternative). PAD-scans superiority in incremental cost-effectiveness ratio occurred at a PAD prevalence threshold of 0.24.DiscussionPAD-scan is a cost-effective test for the detection of PAD in patients with diabetes.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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