• Brian Badgwell, Loretta A Williams, Tsun Hsuan Chen, Charles Cleeland, and Tito Mendoza.
• Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
• Ann. Surg. 2022 Dec 1; 276 (6): e805e811e805-e811.

ObjectiveWe sought to construct a valid and reliable patient-reported outcome measure for patients with advanced malignancy and GIO.BackgroundBowel obstruction is the most common indication for palliative surgical consultation in patients with advanced cancer; however, no validated patient-reported outcome measures exist for this population.MethodsA total of 125 patients with GIO and 64 patients without GIO who underwent palliative surgical consultation completed the MDASI-GIO questionnaire and a single global quality-of-life question. Summary statistics were used to assess the symptom burden of GIO patients. Outcome measures were validity (construct and criterion) and reliability (internal and test-retest) for the MDASI-GIO.ResultsThe majority of patients rated the severity of each of the 5 following GIO-specific symptoms as moderate to severe (rating of ≥5 on a 0 to 10 scale): "being unable to eat'' (72%), "being unable to have a bowel movement'' (65%), "abdominal discomfort'' (62%), "stomach feeling full'' (55%), and "abdominal cramping'' (54%). The MDASI-GIO subscale Cronbach coefficient alpha values were 0.80-0.91, and intraclass correlations were 0.72-0.84. Correlations between MDASI-GIO subscales and global quality of life were -0.39 to-0.49 ( P < 0.001 for all comparisons). GIO patients had significantly worse symptoms and higher interference than did non-GIO patients (all P < 0.05) with effect-size differences of ≥0.36, supporting known-group validity.ConclusionsThe MDASI-GIO shows initial validity and reliability for assessing the severity of symptoms of patients with GIO and the interference of these symptoms in patients' daily functioning.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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