• Bijan Forogh, Hossein Mohamadi, Hamid Reza Fadavi, Seyed Pezhman Madani, Negar Aflakian, Fateme Ghazaie, and Arash Babaei-Ghazani.
• From the Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran (BF, SPM, NA, AB-G); Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran (HM, FG); Mission Pain and Spine, Mission Viejo, California (HRF); and Department of Physical Medicine and Rehabilitation, University of Montreal Health Center, Montreal, Canada (AB-G).
• Am J Phys Med Rehabil. 2021 Feb 1; 100 (2): 168-172.

ObjectiveRecently, ozone injection has been used to treat various musculoskeletal diseases. This study was performed to compare ultrasound-guided corticosteroid versus ozone injections in the treatment of carpal tunnel syndrome.DesignForty patients with mild to moderate carpal tunnel syndrome were enrolled and randomly placed in one of the two groups of receiving a corticosteroid or ozone injection under ultrasound guidance. To determine the effectiveness of both injection techniques and compare their outcomes, visual analog scale and scores of Boston Carpal Tunnel Questionnaire, as well as ultrasound and electrodiagnostic criteria, were followed at 0, 6, and 12 wks after the injection.ResultsBoth groups showed improvement in visual analog scale and Boston Carpal Tunnel Questionnaire at week 6, and this improvement continued until the 12th week after the injections. However, electrodiagnostic values of sensory nerve action potentials and compound motor action potentials latency, and ultrasound carpal tunnel syndrome criteria showed significant improvement only among the subjects in the corticosteroid group at 6 and 12 wks after the injection (P < 0.05).ConclusionsOzone might be as effective as corticosteroid injection in reducing pain and improving the function. Objective improvements in electrodiagnostic and ultrasound criteria of carpal tunnel syndrome were shown only among patients after corticosteroid injection.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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