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Review Case Reports
Rituximab-induced Ileocolitis in a Patient with Gastric MALToma: A Case Report and Literature Review.
- Yoshikazu Tsuzuki, Rie Shiomi, Keigo Ashitani, Kazuya Miyaguchi, Atsushi Osaki, Hideki Ohgo, Rei Kim, Atsushi Sasaki, Taketo Yamada, Yoshitaka Miyakawa, Hidetomo Nakamoto, and Hiroyuki Imaeda.
- Department of Gastroenterology, Saitama Medical University, Japan.
- Intern. Med. 2021 Jan 1; 60 (5): 731-738.
AbstractRituximab (RTX) is effective for treating cancer, but reports of RTX-associated enterocolitis are limited. We herein report the case of a 65-year-old man who developed RTX-induced ileocolitis. He was diagnosed with gastric mucosa-associated lymphoid tissue lymphoma (MALToma) and treated with RTX. He complained of bloody diarrhea after RTX. Mucosal inflammation on colonoscopy indicated RTX-induced ileocolitis. He was treated with corticosteroids, and his symptoms improved. We reviewed the RTX-associated gastrointestinal adverse events and classified the features into ulcerative colitis, Crohn's disease, microscopic colitis, and ileocolitis. To our knowledge, this is the first case of a Japanese patient who developed RTX-induced ileocolitis.
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