• Tahereh Sadeghiyeh, Fatemeh Hosseini Biouki, Mahta Mazaheri, Masoud Zare-Shehneh, Hossein Neamatzadeh, and Zahra Poursharif.
• Department of Psychology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
• J Res Health Sci. 2017 Jun 24; 17 (2): e00383.

BackgroundCommon functional Val158Met polymorphism in the Catechol-O-methyltransferase (COMT) gene may have an impact on an individual's susceptibility to suicide, but individually published results are inconclusive. Therefore, we performed this meta-analysis to provide a more precise estimation of the association between COMT 158G/A (COMT Val158Met) polymorphism and suicide susceptibility.Study DesignA cross-sectional study.MethodsThis systematic review and meta-analysis is a comprehensive literature search of PubMed, Scopus, Web of Science and Google Scholar databases was conducted on case-control studies published up to Mar 2017. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.ResultsWe identified 14 eligible case-control studies, including 2353 suicide attempters and 2593 controls. The pooled results indicated that COMT 158G/A (COMT Val158Met) polymorphism was not significantly associated with increased overall suicide risk. The same results were revealed based on ethnicity, Hardy-Weinberg equilibrium (HWE) status and genotyping technique. However, there was significant association between COMT Val158Met polymorphism and suicide risk among females under the homozygote (AA vs. GG: OR=1.829, 95% CI=1.158-2.889, P=0.010) and recessive (AA vs. AG +GG: OR = 1.787, 95% CI=1.195, 2.671, P=0.005) models, but not among males.ConclusionsCOMT 158G/A (COMT Val158Met) polymorphism was associated with suicide susceptibility only in females.

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