• Kai Sun, Long Liang, He Yin, Jie Yu, Minshan Feng, Jiawen Zhan, Zhefeng Jin, Xunlu Yin, Xu Wei, and Liguo Zhu.
• Department of Spine, Wangjing Hospital of China Academy of Chinese Medical Sciences.
• Medicine (Baltimore). 2019 Dec 1; 98 (49): e18135e18135.

BackgroundDegenerative lumbar spondylolisthesis (DLS) is one of the common orthopedic diseases which causes low back pain in patients, which seriously affects people's daily life and work. As a method of conservative treatment of this disease, manipulation is widely used in clinical practice. We will summarize the current published evidence of manipulation in the treatment of DLS, and evaluate the effectiveness and safety of manipulation through systematic review and meta-analysis, so as to provide more reliable evidence for future clinical practice.MethodsWe will conduct a comprehensive search of the following 9 databases until January 2019: PubMed, Embase, Cochrane Library, ClinicalTrials.gov, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals Database, Wan Fang Database, and Chinese Biomedical Database. The 2 researchers will independently search, screen, extract data, and evaluate the quality of the literatures. The primary outcomes include clinical effectiveness, Japanese Orthopaedic Association scores, and the secondary outcomes include visual analog scale scores, symptom scores, and adverse events. Bias risk tools provided by Cochrane Collaboration will be used for literature quality assessment, and RevMan 5.3 software will be used for meta-analysis.ResultsThe results of this study will systematically evaluate the effectiveness and safety of manipulation intervention for people with DLS, especially in improving lumbar function scores and pain scores.ConclusionThe systematic review of this study will summarize the current published evidence of manipulation for the treatment of DLS, which can further guide the promotion and application of it.Ethics And DisseminationThis study does not require ethical approval and the results will be published in a peer-reviewed journal.Prospero Registration NumberCRD42019139933.

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